Two sample MR report
HLA-DQA1_Alveolar Macrophages against bbj-a-88
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 48 | 0.0882221 | 0.3097571 | 0.7770676 |
| Weighted median | 48 | -0.1687829 | 0.0139405 | 0.0000000 |
| Inverse variance weighted | 48 | -0.0732894 | 0.0269637 | 0.0065663 |
| Simple mode | 48 | -0.2039447 | 0.0132754 | 0.0000000 |
| Weighted mode | 48 | -0.1958342 | 0.0113027 | 0.0000000 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 1023.439 | 46 | 0 |
| Inverse variance weighted | 1029.534 | 47 | 0 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0893847 | 0.1707667 | 0.6031867 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0007201 | 5.6e-06 | TRUE | 0.0196461 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
